Adding a certain compound to certain chemical reactions, such as: 76469-41-5, 2,3,5-Trifluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 76469-41-5, blongs to pyridine-derivatives compound. Formula: C5H2F3N
A mixture of 2, 3, 5-trifluoropyridine (5.0 g, 37.6 mmol, 1.0 equiv) and 1, 3-dimethyl propanedioate (7.4 g, 56.0 mmol, 1.5 equiv) and Cs 2CO 3 (24.5 g, 75.2 mmol, 2.0 equiv) in DMSO (100.0 mL) was stirred for 10 hours at 100C under nitrogen atmosphere. The resulting mixture was extracted with EtOAc (4 x 50 mL). The combined organic layers were washed with H2O (3 x 50 mL), dried over anhydrous Na 2SO 4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EtOAc (20: 1) to afford 1, 3-dimethyl 2- (3, 5-difluoropyridin-2-yl) propanedioate (8.1 g, 79.13%) as a yellow oil. LCMS: m/z (ESI), [M+H] + = 246.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76469-41-5, its application will become more common.
Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; ZENG, Qingbei; QI, Changhe; TSUI, Honchung; YANG, Zhenfan; ZHANG, Xiaolin; (206 pag.)WO2020/52631; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem