Application of 72990-37-5 , The common heterocyclic compound, 72990-37-5, name is 3-Chloroisonicotinaldehyde, molecular formula is C6H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 3-chloropyridine-4-carbaldehyde (3.58 g, 25.3 mmol) in MeOH(150 mL) at 0 C was added NaBH4 (1.91 g, 50.6 mmol) portion wise. The mixture was stirred at this temperature for 5 min then allowed to warm up to rt and stirred at this temperature for 1.5 h. The reaction mixture was quenched with saturated aqueous solution of NH4Cl. Volatiles were removed in vacuo and the aqueous layer was extracted with EtOAc (150 mL). The organic layer was washed successively with water (150 mL) and brine (150 mL), dried over Na2SO4, filtered and concentrated in vacuo to give chloropyridine 33 (3.58 g, 99%) as a white solid which was used in the next step without further purification.
The synthetic route of 72990-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jepsen, Tue Heesgaard; Glibstrup, Emil; Crestey, Francois; Jensen, Anders A.; Kristensen, Jesper Langgaard; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 988 – 994;,
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