Adding a certain compound to certain chemical reactions, such as: 6602-32-0, 2-Bromo-3-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-3-hydroxypyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Bromo-3-hydroxypyridine
Diethyl azodicarboxylate (95 mL, 0.6 mol) was added dropwise to a stirred mixture of 2-bromo-3- hydroxypyridine (97 g, 0.55 mol), 3-buten-l-ol (47.7 mL, 0.55 mol), and PPh3 (175.3 g, 0.66 mol) in THF (970 mL) at 0C under a N2 atmosphere. The reaction mixture was warmed to 50C in an oil bath and stirred for 17.5 h. Reaction progress was monitored by TLC (15% EtOAc in hexane, UV active). The reaction mixture was cooled to ambient temperature and diluted with saturated NaHC03 solution (500 n L). The aqueous solution was extracted with EtOAc (1 L). The organic layer was dried over Na2S04 (200 g), and concentrated. The residual product was purified by column chromatography using 60-120 mesh, eluting with 5% EtOAc in hexane to afford the title compound as a pale yellow oil. MS (ESI) m/z; 228 (MH+).
The synthetic route of 6602-32-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NANT HOLDINGS IP, LLC; NANTWORKS, LLC; TAO, Chunlin; WANG, Qinwei; SOON-SHIONG, Patrick; (94 pag.)WO2017/24315; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem