Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 159503-91-0, name is tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C10H16BrNO2
In the third step, a Grignard exchange reaction of 26.21 g (0.1 mol) of N-Boc piperidin-4-enyl bromide with 12.9 g (0.105 mol) of isopropyl bromide in tetrahydrofuran, and then, under the protection of nitrogen, At 0 C, 19.03 g (0.11 mol) of pinacol methoxyboronic acid was added dropwise to the Grignard reaction solution, the reaction was held for 4 h, and then the temperature was raised to reflux for 1 h. After the reaction was completed, 10 ml of 10% dilute hydrochloric acid was added to quench the reaction. After the solvent was distilled off, 120 ml of ethanol was added for beating. The white solid was filtered to obtain 26.9 g, and the yield was 87%.
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Reference:
Patent; Zhonghao (Dalian) Chemical Design Yuan Co., Ltd.; Wang Kewei; Cai Xiaochuan; Zhao Wenwu; Tang Peikun; Han Jianguo; (6 pag.)CN110526936; (2019); A;,
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