Application of 56055-54-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56055-54-0, name is Methyl 5,6-dichloronicotinate. A new synthetic method of this compound is introduced below.
Step B: Methyl 5-chloro-6- (2, 2, 2-trifluoro-1-methylethoxy) nicotinate; To a solution of 630 mg (3.06 mmol) of methyl 5,6-dichloronicotinate (from Step A) and 349 muL (3.06 mmol) of 1, 1, l-trifluoro-2-propanol in 10 mL of THF at-78 C was added 3.1 mL (3.06 mmol) of sodium bis (trimethylsilyl) amide (1.0 M in THF). After stirring at-78 C for 30 min and at 0 C for 5 h, the reaction was quenched by adding 10 mL of saturated NH4Cl. The mixture was poured into brine and extracted with CH2C12 (3 x 20 mL). Organic layers were combined, dried over MgS04, and concentrated. Chromatography on a Biotage 40M cartridge using 3: 97 v/v Et20/hexanes as the eluant gave 627 mg of the title compound : 1H NMR (500 MHz, CDC13) 8 1.56 (d, J = 6.4, 3H), 3.93 (s, 3H), 5.86 (m, 1H), 8.27 (d, J = 2.1, 1H), 8. 67 (d, J = 2.0, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56055-54-0, Methyl 5,6-dichloronicotinate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2005/58848; (2005); A1;,
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