Electric Literature of 148493-37-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148493-37-2, name is 2,6-Dichloro-3-iodopyridine. A new synthetic method of this compound is introduced below.
To a degassed solution of2,6-dichloro-3-iodopyridine (3.0 g, 11 mmol) and (E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.2 g, 11 mmol) in 1,4- dioxane (20mL) and water (1.0 mL) was added CS2C03 (7.1 g, 22 mmol) and 1, 1′-bis(di-tertbutylphosphino)ferrocene palladium chloride (357 mg, 0.54 mmol) under N2 protection. The resulting mixture was heated to 70 oc and stirred at this temperature overnight. The reactionwas cooled, filtered through a pad of the celite and washed with ethyl acetate. The combinedfiltrate was evaporated in vacuo. The resulting residue was purified using columnchromatography (eluted with 0-20% EtOAc I DCM) to provide (E)-2,6-dichloro-3-(2-5 ethoxyvinyl)pyridine (1.96 mg, yield: 86%). MS (M+Ht: 218.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,148493-37-2, 2,6-Dichloro-3-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; BROCKUNIER, Linda L.; NARGUND, Ravi; MARCANTONIO, Karen; ZORN, Nicolas; XIAO, Dong; PENG, Xuanjia; LI, Peng; GUO, Tao; WO2014/121416; (2014); A1;,
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