Adding a certain compound to certain chemical reactions, such as: 106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5NO2, blongs to pyridine-derivatives compound. COA of Formula: C6H5NO2
Synthesis of Example 25: [Show Image] To a solution of intermediate 12e (417 mg, 1.00 mmol) in acetonitrile (20 mL) and acetic acid (200 muL) was added 6-hydroxynicotinaldehyde (123 mg, 1.00 mmol). The reaction mixture was stirred vigorously at reflux temperature overnight. The solvent was removed under reduced pressure. The crude product was purified by preparative LC-MS. The pure product (213 mg, 0.41 mmol, brown sticky solid) was dissolved in methanol (5 mL) and 1 M HCl in diethyl ether (820 muL, 0.82 mmol) was added. The solvents were removed under reduced pressure. The product was taken up in water (5 mL) and lyophilized
The synthetic route of 106984-91-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem