Adding a certain compound to certain chemical reactions, such as: 89488-29-9, 2-Bromo-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89488-29-9, blongs to pyridine-derivatives compound. Computed Properties of C6H6BrNO
PdCI2(dppf) (0.065 g, 0.08 mmol, 0.05 eq) was added to a solution of compound 52h (0.6 g, 1.58 mmol, 1 eq), potassium acetate (0.31 g, 3.17 mmol, 2 eq) and bis(pinacolato)diboron (0.8 g, 3.17 mmol, 2 eq) in dioxane that was stirred under Ar at rt. The reaction mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml) and brine (20 ml), dried over Na2S04 and concentrated. The pinacol boronate (0.7 g) thus obtained was dissolved in dioxane (25 ml). 2-bromo-4-methoxypyridine (0.265 g, 1.41 mmol), 10% aqueous K2C03 solution (3.5 ml) and finally tetrakis(triphenylphosphine)palladium(0) (0.07 g, 0.06 mmol) were added. The mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml), brine (20 ml), dried over Na2S04 and concentrated. The remnant was purified by column chromatography [EtOAc/hexane = 1 :1 ]. White solid. Yield: 0.27 g. m/z: [M+H]+ = 406.8.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89488-29-9, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; KONETZKI, Ingo; JAKOB, Florian; WAGENER, Markus; WELBERS, Andre; HESSLINGER, Christian; (168 pag.)WO2017/108204; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem