Application of 157402-44-3 ,Some common heterocyclic compound, 157402-44-3, molecular formula is C12H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a vigorously-stirred solution of 6-phenyl-2-pyhdine aldehyde (0.50 g, 2.73 mmol) in 30 mL of anhydrous Et2O under N2, was added a solution of methyllithium (1.7 mL of 1.6 M solution in Et2O, 3.0 mmol) at ambient temperature. After 12 h, the reaction was quenched with 5 mL saturated aqueous ammonium chloride. This solution was extracted with 3 x 10 mL EtOAc. The organic fractions were pooled, dried over Na2SO4 and concentrated. After removing the volatiles in vacuo, the resultant yellow oil was chromatographed on silica with 10% EtOAc/hexanes. Clean fractions were combined and the volatiles were removed to provide 0.25 g of the product as a yellow oil (50%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 157402-44-3, 6-Phenylpicolinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2008/85658; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem