With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59237-53-5, name is Methyl 6-chloro-5-nitronicotinate, molecular formula is C7H5ClN2O4, molecular weight is 216.58, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl 6-chloro-5-nitronicotinate
A stirred solution of commercially available methyl 6-chloro–nitronicotinate (1.0 g,4.62 mmol) in THF (20 mL) was degassed with N2, and then ethynyltrimethylsilane (0.544 g, 5.54 mmol), Pd(PPh3)2C12 (0.324 g, 0.46 mmol), CuT (0.017 g, 0.089 mmol) and triethylamine (10 mL) were added sequentially. The resulting reaction mixture was heated at 80 oC for 3 h. Completion of the reaction was monitored by TLC and LCMSafter which the reaction mixture was diluted with water and extracted with EtOAc. The combined organics were washed with brine solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product which was purified by column chromatography to provide titled compound (o.6 g, 46.6percent yield and purity 98percent) as an oily liquid. LCMS m/z: 279 [M+H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59237-53-5, Methyl 6-chloro-5-nitronicotinate, and friends who are interested can also refer to it.
Reference:
Patent; CURADEV PHARMA LIMITED; BANERJEE, Monali; MIDDYA, Sandip; BASU, Sourav; GHOSH, Rajib; PRYDE, David; YADAV, Dharmendra; SHRIVASTAVA, Ritesh; SURYA, Arjun; (290 pag.)WO2018/234808; (2018); A1;,
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