The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65515-28-8, name is Methyl 2,6-dichloronicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H5Cl2NO2
[Example 24] Synthesis of 2-chloro-6-phenyl-nicotinic acid methyl ester To the mixture of 2,6-dichloro-nicotinic acid methyl ester (4.0 g, 19 mmol) synthesised in Example 23 and tetrahydrofuran (39 ml), phenyl boronic acid (2.5 g, 19 mmol), potassium carbonate (8.0 g, 58 mmol), and tetrakis(triphenylphosphine)palladium(0) (1.2 g, 0.97 mmol) were added, and the obtained reaction mixture was stirred for 16 hours while being heated to reflux. The reaction mixture was cooled to room temperature, and then insoluble matter was removed by filtration. The solvents were evaporated under reduced pressure from the filtrate, and then water and ethyl acetate were added to the obtained residue, followed by extraction. The organic layer and the aqueous layer were separated, and the aqueous layer was further extracted using ethyl acetate. The organic layers were mixed, washed with saturated saline, and dried using anhydrous sodium sulfate. The solvents were evaporated under reduced pressure, and the obtained residue was purified with silica gel column chromatography (heptane: ethyl acetate = 10:1 to 3:1). The obtained crude compound was recrystallized using the mixed solvent of heptane-diethyl ether, thereby obtaining the entitled compound (2.2 g, 47%). 1H-NMR Spectrum (CDCl3) delta(ppm): 3.98(3H, s), 7.46-7.53(3H, m), 7.74(1H, d, J=8.0Hz), 8.04-8.08(2H, m), 8.25(1H, d, J=8.0Hz)
With the rapid development of chemical substances, we look forward to future research findings about 65515-28-8.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2062901; (2009); A1;,
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