Related Products of 881-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 881-86-7, name is Dimethyl pyridine-2,5-dicarboxylate, molecular formula is C9H9NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Pyridine 2,5-dicarboxylic acid 5-methyl ester. Pyridine 2,5-dicarboxylic acid 5-methyl ester was synthesised according to the procedure described by Faul, M. M., et al., (J. Org. Chem. 66, 5772-5782, 2002). Di-ester (28 g, 0.146 moles) and methanol (260 mL) were stirred in a 500 mL 3-neck round bottom flask with connected a condenser and a funnel. The reaction mixture was heated at reflux after adding one portion of NaOH (6.2 g, 0.155 moles) for 3 h 30 min to produce a white mixture. While at reflux, 2M HCl (121 mL) was added dropwise over a 1 h period to produce a yellow solution. The flask was placed in an ice water bath to cool, and at r.t., a precipitate appears. The precipitate was collected by filtration and washed with 2:1 MeOH/H2O (35 mL) and then water (50 mL). The precipitate was dried overnight. The final yield was 19.68 g (75percent). NMR 1H 300 MHz, DMSO-d6 (delta, ppm): 9.12 (m, 1H), 8.40 (dd, J=2.1 Hz and 8.1 Hz, 1H, CH), 8.12 (dd, J=0.9 Hz and 8.4 Hz, 1H, CH), 3.89 (s, 3H, CH3). NMR 13C 75.45 MHz, DMSO-d6 (delta, ppm): 165.9, 165.0, 152.1, 150.2, 138.8, 128.3, 125.0, 53.2.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 881-86-7, Dimethyl pyridine-2,5-dicarboxylate.
Reference:
Patent; Washington, University of; US2008/103192; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem