Adding a certain compound to certain chemical reactions, such as: 944317-53-7, 4-Methyl-5-nitro-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H5F3N2O2, blongs to pyridine-derivatives compound. COA of Formula: C7H5F3N2O2
Into a 1L 3-necked round-bottom flask was placed 4-methyl-5-nitro-2- (trifluoromethyl)pyridine (60 g, 291.26 mmol, 1 equiv), Fe (48.9 g, 873.79 mmol, 3 equiv), NH4CI (77.2 g, 1456.31 mmol, 5 equiv), and H2O (500 mL). The resulting mixture was stirred for 2 at 80 C. The resulting solution was extracted with ethyl acetate. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1/10) to give (27 g, 60.76%) of the title compound as a white solid. LC-MS: (ES, m/z): [M+H]+ 177.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,944317-53-7, 4-Methyl-5-nitro-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; IDEAYA BIOSCIENCES, INC.; ALAM, Muzaffar; BECK, Hilary, Plake; DILLON, Michael, Patrick; GONZALEZ-LOPEZ, Marcos; SUTTON, James, Clifford, Jr.; (248 pag.)WO2019/156987; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem