Synthetic Route of 102368-13-8 ,Some common heterocyclic compound, 102368-13-8, molecular formula is C11H8N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide (570 mg, 2.35 mmol), 1,1′-thiocarbonyldi-2(1H)-pyridone (550 mg, 2.35 mmol) and dioxane (20 mL) is stirred at reflux overnight. The reaction mixture is concentrated, diluted with DCM, filtered through a pad of silica gel and the filtrate is concentrated to give the title compound.Yield: 440 mg (65%). Rf=0.80 (silica gel, DCM:EtOH 95:5).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,102368-13-8, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/149676; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem