Electric Literature of 779345-37-8, Adding some certain compound to certain chemical reactions, such as: 779345-37-8, name is 5-Fluoro-2-nitropyridine,molecular formula is C5H3FN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 779345-37-8.
Synthesis of compound 224.1. To a solution of 220.1 (0.300g, 2.1 lmmol, l .Oeq) in DMSO(5ml) was added 2-methylpropan-2-amine (0.185g, 2.533mmol, 1.2eq.) and DIPEA (2.72g, 21.1 lmmol, lO.Oeq.). The reaction mixture was heated at 100 C for lh. After completion of reaction, mixture was poured in water, quenched with NH4C1 solution and extracted with EtOAc. Organic layers were combined, dried over sodium sulphate and concentrated under reduced pressure to obtain crude which was purified by chromatography to get pure 224.1 (0.225g, 54.59%). MS(ES): m/z 195.22 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 779345-37-8, 5-Fluoro-2-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem