Electric Literature of 1462-86-8, Adding some certain compound to certain chemical reactions, such as: 1462-86-8, name is 3-Aminopicolinic acid,molecular formula is C6H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1462-86-8.
General procedure: In a vial, 0.088 mmol (1.2 equiv) of the 3-aminopicolinic acid were added and dissolved in 0.5 mL mixture of DCM:DIEA (9:1), then 41 mg (0.110 mmol, 1.5 equiv) of HATU were added. The mixture was stirred for 10 min, and 20 mg (0.073 mmol, 1.0 equiv) N-(4-aminophenyl)phthalimide dissolved in 0.5 mL of DCM:DIEA (9:1), followed by 3 drops of DMF. The reaction was stirred for 24 h at room temperature. After this time, the reaction was quenched with the addition of water, and was worked up by extraction with DCM (2 mL, thrice). The organic phased was filtered through a phase separator, volatiles were evaporated, the crude was dissolved in DMSO and purified by preparative HPLC.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1462-86-8, 3-Aminopicolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Gogliotti, Rocco D.; Engers, Darren W.; Garcia-Barrantes, Pedro M.; Panarese, Joseph D.; Gentry, Patrick R.; Blobaum, Anna L.; Morrison, Ryan D.; Daniels, J. Scott; Thompson, Analisa D.; Jones, Carrie K.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 12; (2016); p. 2915 – 2919;,
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