With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1211537-08-4, name is 4,5-Difluoropyridin-2-amine, molecular formula is C5H4F2N2, molecular weight is 130.1, as common compound, the synthetic route is as follows.SDS of cas: 1211537-08-4
36 · 8 g (0 · 28 mol) of 2-amino-4,5-difluoropyridine, 40 · 57 g (0 · 23 mol) of D-glucopyranose and acetonitrile with 10% hydrochloric acid solution (volume ratio 1: 1) A mixture of 200 ml was added to a 500 ml round bottom flask, heated to reflux for 30 minutes, naturally cooled to room temperature, suction filtered, recrystallized from a mixture of acetonitrile:ethanol = 2:1, dried at 60 C vacuum. 10 hours, get 61.15 grams of white solid product, the yield is 90.97%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211537-08-4, 4,5-Difluoropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; Henan Chemical Institute Co., Ltd.; Huo Erfu; Cheng Weiqin; Feng Ming; Wang Bonan; Wang Yanhua; Yang Shuai; Wang Yinan; Yang Xianhong; Wang Fang; Han Juan; Zhang Qianhua; Liu Xiuwei; Gao Qinghuan; (17 pag.)CN109824742; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem