Synthetic Route of 100367-39-3, Adding some certain compound to certain chemical reactions, such as: 100367-39-3, name is 4-Bromo-2-methoxypyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100367-39-3.
To a resealable reaction pressure vessel under nitrogen wasadded 1.0 equiv of 9 (266 mg, 0.665 mmol), Pd(PPh3)4 (38 mg,0.033 mmol, 5 mol %), K2CO3 (184 mg, 1.33 mmol, 2.0 equiv), 2-methoxy-4-bromopyridine (137 mg, 0.732 mmol, 1.1 equiv),dioxane (20 mL) and water (2 mL). The mixture was degassedthrough bubbling nitrogen for 40 min and heated at 110 C overnight.After cooling to room temperature, water (20 mL) wasadded and the organic product was extracted using EtOAc(3 30 mL). The combined organic layers were dried overMgSO4, filtered through Celite and the solvent removed in vacuo.The residual was purified on a silica gel column eluted withEtOAc/hexanes to provide 160 mg (63%) of 8e as a colorless oil.
According to the analysis of related databases, 100367-39-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ondachi, Pauline W.; Ye, Zhuo; Castro, Ana H.; Luetje, Charles W.; Damaj, M. Imad; Mascarella, S. Wayne; Navarro, Hernan A.; Carroll, F. Ivy; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5693 – 5701;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem