Synthetic Route of 19337-97-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19337-97-4, name is trans-3-(3-Pyridyl)acrylic acid, molecular formula is C8H7NO2, molecular weight is 149.15, as common compound, the synthetic route is as follows.
General procedure: Compound 1c-9c (1.0mmol) was dissolved in anhydrous tetrahydrofuran (20mL). To the solution, triethylamine (1.2mmol) was slowly added and the solution was cooled to-20C, pivaloyl chloride (1.2mmol) was then added, and the reaction mixture was stirred for about 45min. Next, the compound 13 or 15 and n-butyllithium were added to the reaction solution and stirred for 1h, checked for product formation via TLC. Then saturated aqueous solution of ammonium chloride (10mL) was added to quench the n-butyllithium in the reaction and extracted with ethyl acetate, the organic phase was washed with saturated brine (30mL×3), Dried over anhydrous sodium sulfate, concentrated and purified by column chromatography (PE/EA=3: 1) to afford 1-9.
Statistics shows that 19337-97-4 is playing an increasingly important role. we look forward to future research findings about trans-3-(3-Pyridyl)acrylic acid.
Reference:
Article; Zou, Yu; Yan, Chang; Zhang, Huibin; Xu, Jinyi; Zhang, Dayong; Huang, Zhangjian; Zhang, Yihua; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 313 – 319;,
Pyridine – Wikipedia,
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