Adding a certain compound to certain chemical reactions, such as: 55279-29-3, 3-Aminoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Example 3 [0159] 3-aminonicotinaldehyde (50 mg, 0.41 mmol) and 1 -(2-chloro-5- nitrophenyl)ethanone (82 mg, 0.41 mmol) were put into ethanol (1 ml_), and then added NaOH (0.3 mg, 0.01 mmol) at room temperature. The solution was heated to 70 C and stirred at this temperature for overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to yield the desired product (38 mg, 33 % yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 9.50 (s, 1 H), 8.71 (d, J = 5.2 Hz, 1 H), 8.63 (d, J = 8.4 Hz, 1 H), 8.53 (d, J = 2.8 Hz, 1 H), 8.40-8.37 (m, 1 H), 8.16 (d, J = 8.8 Hz, 1 H), 8.04-8.02 (m, 1 H), 7.99-7.97 (m, 1 H). MS (ESI): Calcd. for Ci4H8CIN3O2: 285, found 286 (M+H)+.
The synthetic route of 55279-29-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NANT HOLDINGS IP, LLC; TAO, Chunlin; YU, Chengzhi; ARP, Forrest; WEINGARTEN, Paul; SOON-SHIONG, Patrick; WO2014/71298; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem