Reference of 13466-38-1 ,Some common heterocyclic compound, 13466-38-1, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of 5-bromopyridin-2-ol (10 g, 57.5 mmol) in anhydrous THF (200 ml) at RT was added hydroxypivalic acid methyl ester (9.16 ml, 71.8 mmol).Triphenylphosphine (18.8 g, 71.8 mmol) was then added followed by dropwise addition ofdiisopropyl azodicarboxylate (14.1 ml, 71.8 mmol) at OoC. The reaction was then heated to 55C and allowed to stir at this temperature over night. The reaction mixture was concentrated. The residue was treated with EtOAc (70 ml) and then Hexane (70 ml), the solid was filtered off. The filtrate was concentrated, separated by MPLC (10-100% EtoAC in hexane) to give methyl 3-(5-bromopyridin-2-yloxy)-2,2-dimethylpropanoate (9.94 g). LC-MS (ES, mlz) C11H14BrNO3: 287; Found: 288 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13466-38-1, 5-Bromopyridin-2-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DEVITA, Robert, J.; YU, Yang; LIU, Jian; HE, Shuwen; KRIKORIAN, Arto, D.; MILLER, Daniel, J.; WU, Zhicai; YANG, Ginger Xu-Qiang; HONG, Quingmei; LAI, Zhong; ZORN, Nicolas; TING, Pauline, C.; WO2013/130370; (2013); A2;,
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