Related Products of 133081-24-0 ,Some common heterocyclic compound, 133081-24-0, molecular formula is C6H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Water was purified and deionized (18 MOmega/cm2) via a Milli-Q water filtration system (Millipore Corp., Milford, MA). 99Mo-99mTc generators were purchased from TecnoNuclear (Argentina). High performance liquid chromatography (HPLC) was performed on an HPLC Varian 5000 Liquid Chromatograph, integrator 4290 Varian, simultaneous detection by NaI (Tl) crystal detector (ORTEC)) and UV detector (lambda= 254 nm), Column Thermo Scientific Hypersil ODS (C18) (300 mm × 4.6 × 10 mum). The flow rate was 1mL/min used with a gradient mobile phase from 100% of A (0.1% TFA in H2O) to 100% of B (0.1% TFA in acetonitrile) in 20 min. Labeling conditions: 1 mL of HYNIC-hydrazone in DMSO (1mg/mL) was incubated with 0.4 mL of tricine solution (100 mg/mL in water), 0.2 mL nicotinic acid solution (10 mg/ml in water), 100 muL of 99mTcO4- (37-111 MBq) and 15 muL of SnCl2.2H2O (1 mg/mL in nitrogen-purged 0.1 M HCl) for 60 min at 70 oC tofinal pH 5. The reaction was analyzed for radiochemical purity by HPLC. CPS: counts per second.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133081-24-0, 6-Hydrazinylnicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Teixeira, Vania; Cabral, Pablo; Porcal, Williams; Arkivoc; vol. 2018; 5; (2018); p. 29 – 38;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem