An article Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts WOS:000525788200001 published article about OLD YELLOW ENZYME; COMBINING PHOTOCATALYSIS; BIOCATALYTIC REDUCTION; RADICALS; BOND; DISSOCIATION; REDOX; HETEROCYCLES; BIOREDUCTION; COMPLEXES in [Nakano, Yuji; Black, Michael J.; Meichan, Andrew J.; Sandoval, Braddock A.; Chung, Megan M.; Biegasiewicz, Kyle F.; Hyster, Todd K.] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA; [Zhu, Tianyu] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA; [Nakano, Yuji] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia; [Biegasiewicz, Kyle F.] Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA in 2020, Cited 61. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Name: Phenyl(pyridin-2-yl)methanone
Flavin-dependent ‘ene’-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Experimental evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution. DFT calculations reveal this radical to be dynamically stable, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models.
Name: Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Nakano, Y; Black, MJ; Meichan, AJ; Sandoval, BA; Chung, MM; Biegasiewicz, KF; Zhu, TY; Hyster, TK or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem