An article 4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis WOS:000457961800001 published article about MONOAMINE-OXIDASE-B; HIGH-POTENCY; IN-VITRO; MAO; SCAFFOLD; DESIGN; AGENTS; IDENTIFICATION in [Secci, Daniela; Guglielmi, Paolo; D’Ascenzio, Melissa; Chimenti, Paola] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Rome, Italy; [Carradori, Simone] G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa; [Bagetta, Donatella; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Catanzaro, Italy; [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey; [D’Ascenzio, Melissa] Univ Dundee, Sch Life Sci, DArcy Thompson Unit, Dundee DD1 4HN, Scotland in 2019.0, Cited 51.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure-activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.
About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Secci, D; Carradori, S; Petzer, A; Guglielmi, P; D’Ascenzio, M; Chimenti, P; Bagetta, D; Alcaro, S; Zengin, G; Petzer, JP; Ortuso, F or concate me.. Name: 3-Pyridinecarboxaldehyde
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem