Recently I am researching about RESISTANCE MECHANISMS; NITROIMIDAZOLE DRUGS; COMPLEXES; LEISHMANIASIS; REDUCTION; DESIGN; SERIES, Saw an article supported by the Conselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ); Coordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa do Estado de Minas GeraisFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG). Published in INT UNION CRYSTALLOGRAPHY in CHESTER ,Authors: Oliveira, APA; Ferreira, IP; Despaigne, AAR; da Silva, JG; Vieira, ACS; Santos, MS; Alexandre-Moreira, MS; Diniz, R; Beraldo, H. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Application In Synthesis of Phenyl(pyridin-2-yl)methanone
Three imidazole hydrazone compounds, namely 2-(4-nitro-1H-imidazol-1-yl)-N’-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (1), 2-(2-nitro-1H-imidazol-1-yl)-N’-[1-(pyridin-2-yl)ethylidene]acetohydrazide, C12H12N6O3, (2), and 2-(2-nitro-1H-imidazol-1-yl)-N’-[(phenyl)(pyridin-2-yl)methylidene]acetohydrazide, C17H14N6O3, (3), were obtained and fully characterized, including their crystal structure determinations. While all the compounds proved not to be cytotoxic to J774.A1 macrophage cells, (1) and (3) exhibited activity against Leishmania chagasi, whereas (2) was revealed to be inactive. Since both (1) and (3) exhibited antileishmanial effects, while (2) was devoid of activity, the presence of the acetyl or benzoyl groups was possibly not a determining factor in the observed antiprotozoal activity. In contrast, since (1) and (3) are 4-nitroimidazole derivatives and (2) is a 2-nitroimidazole-derived compound, the presence of the 4-nitro group probably favours antileishmanial activity over the 2-nitro group. The results suggested that further investigations on compounds (1) and (3) as bioreducible antileishmanial prodrug candidates are called for.
Application In Synthesis of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Oliveira, APA; Ferreira, IP; Despaigne, AAR; da Silva, JG; Vieira, ACS; Santos, MS; Alexandre-Moreira, MS; Diniz, R; Beraldo, H or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem