614-18-6, Adding a certain compound to certain chemical reactions, such as: 614-18-6, Ethyl nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 614-18-6, blongs to pyridine-derivatives compound.
Nicotinic acid ethyl ester 4 (1.5g, 10mmol) was dissolved in15mL of ethanol, then under ice-cooling was slowly added dropwise with hydrazine hydrate (2g, 40mmol), after the addition was complete, it was stirred at room temperature for 15min, then heated under reflux for 10h. After completion of the reaction, ethanol was removed by rotary evaporation, poured into water, extracted with ethyl acetate, the organic phase was dried andconcentrated to give the desired product 5 (1.1g, 78%), without purification into the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,614-18-6, its application will become more common.
Reference:
Patent; Jiangshu Alpha Biopharmaceuticals, Inc.; Jiangnan University; Nanjing Drum Tower Hospital; Feng, Bainian; Yang, Guijun; Tang, Chunlei; Wang, Guping; Jie, Desheng; (36 pag.)CN105481765; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem