630120-99-9 , The common heterocyclic compound, 630120-99-9, name is 5-(Benzyloxy)-2-bromopyridine, molecular formula is C12H10BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(1) The compound (201 mg) obtained in Reference Example 1-1-(1), 4H-1,2,4-triazole (63.1 mg), copper (II) acetate monohydrate (76.0 mg), and cesium carbonate (744 mg) were suspended in N,N-dimethylformamide (4 mL), and the mixture was deaerated, so that the air in the container was purged with nitrogen. The mixture was stirred under microwave irradiation at 120C for 1 hour and then stirred in oil bath at 160C for 7 hours. The mixture was cooled to room temperature, and then subjected to removal of insolubles by celite filtration and washing with ethyl acetate. An aqueous solution of saturated ammonium chloride was added to the mixture of filtrate and washing solution, the mixture was shaken, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with water and then brine, and was separated by a phase separator, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane/ethyl acetate = 1:1 to ethyl acetate only) to give 5-phenylmethoxy-2-(1,2,4-triazol-1-yl)pyridine (129 mg) as a colorless powder.
According to the analysis of related databases, 630120-99-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TANAKA, Hiroaki; BOHNO, Ayako; HAMADA, Makoto; ITO, Yuji; KOBASHI, Yohei; KAWAMURA, Madoka; (235 pag.)EP3418276; (2018); A1;,
Pyridine – Wikipedia,
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