581-45-3, Adding a certain compound to certain chemical reactions, such as: 581-45-3, 4-(Piperidin-4-yl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 581-45-3, blongs to pyridine-derivatives compound.
4-Nitrophenyl chlorofonnate (183 mg; 0.91 mmol) was added under an argon atmosphere, at 0C, to a solution of F2 (370 mg; 0.82 mmol) and DIPEA (287 ul ; 1.65 mmol) in CH2C12 (10 ml). The mixture was stirred at 0C for 30 minutes. 4-Piperidin-4-yl pyridine (186 mg ; 1.15 mmol) was added. The mixture was stirred for 16 hours and was purified by flash chromatography with increasingly polar solutions of EtOAc/CH2C12 (0-100% EtOAc) and then MeOH/CH2Cl2 (0-15% MeOH) to give RIO as a pale yellow solid (190 mg). Yield: 36 %
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,581-45-3, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/79805; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem