10201-73-7 , The common heterocyclic compound, 10201-73-7, name is 2-Amino-4-methoxypyridine, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add (1.0 mmol, 0.188 g) to a 50 mL pear-shaped flask3-acetylcoumarin, (1.4 mmol, 0.174 g) of 2-amino-4-methoxypyridine, and (1.0 mmol, 0.254 g) of iodine as a catalyst. The mixture in the pear shaped bottle is at 110 CAfter stirring for 4 h, it was cooled to 70 C and stirred overnight. Then add 5mL of distilled water and 0.6mL of mass fraction of 45%Sodium hydroxide solution (adjust the pH of the solution to 12), the mixture is stirred at 100 C for 1 h, cooled to room temperature, and addedNeutralize with 0.3 mL of 10% by mass of dilute hydrochloric acid until a neutral solution is obtained. Extracted 3 times with dichloromethane (each time25 mL), combined with extract phase, dried over anhydrous sodium sulfate, concentrated to remove solvent, then column chromatography (eluent: V acetic acid)Ethyl ester/V petroleum ether = 1:2) isolated to give a brownish-yellow product 3-(7-methoxy-2-imidazo[1,2a]pyridine)-coumarinCalled HP2) (0.152g, yield 52.2%)
The synthetic route of 10201-73-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Li Yujin; Zhou Zichun; Gao Jianrong; Han Liang; Ye Qing; (18 pag.)CN109943092; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem