An article Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies WOS:000462472500011 published article about ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO EVALUATION; DERIVATIVES; BENZOTHIADIAZOLE; COMPLEXES; POLYMERS; DESIGN in [Almandil, Noor Barak; Taha, Muhammad; Ibrahim, Mohamed; Mosaddik, Ashik] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Imran, Syahrul] Univ Teknol MARA UiTM, Atta ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor De, Malaysia; [Alqahtani, Mohammed A.; Bamarouf, Yasser A.; Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, CCSIT, POB 1982, Dammam 31441, Saudi Arabia in 2019.0, Cited 54.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
New series of quinoline-based thiadiazole analogs (1-20) were synthesized, characterized by EI-MS, H-1 NMR and C-13 NMR. All synthesized compounds were subjected to their antileishmanial potential. Sixteen analogs 1-10, 12, 13, 16, 17, 18 and 19 with IC50 values in the range of 0.04 +/- 0.01 to 5.60 +/- 0.21 mu M showed tremendously potent inhibition as compared to the standard pentamidine with IC50 value 7.02 +/- 0.09 mu M. Analogs 11, 14, 15 and 20 with IC50 8.20 +/- 0.35, 9.20 +/- 0.40, 7.20 +/- 0.20 and 9.60 +/- 0.40 mu M respectively showed good inhibition when compared with the standard. Structure-activity relationships have been also established for all compounds. Molecular docking studies were performed to determine the binding interaction of the compounds with the active site target.
COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Almandil, NB; Taha, M; Rahim, F; Wadood, A; Imran, S; Alqahtani, MA; Bamarouf, YA; Ibrahim, M; Mosaddik, A; Gollapalli, M or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem