Analyzing the synthesis route of 183610-70-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

183610-70-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-trifluoromethylpyridin-2-ylamine (Fluorochem Ltd , Derbyshire, United Kingdom 5 37 g, 32 8 mmol) in 100 ml of dry CH3CN under argon were added N- bromosuccinimide (645 g, 36 2 mmol) in 4 equal portions over a period of 1 h at 0-5C The cooling bath was removed and stirring was continued for 3 h The solvent was evaporated under vacuum, then the residue was dissolved in EtOAc and washed with water and brine The organic layer was dned over Na?SO and evaporated to give the title compound as a orange oil. (M+H = 239, 241).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; KALTHOFF, Frank Stephan; MAH, Robert; RAGOT, Christian; STAUFFER, Frederic; WO2010/139731; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem