Safety of 3-Pyridinecarboxaldehyde. Chen, YJ; Xiang, Y; He, YH; Guan, Z in [Chen, Yu-Jue; Xiang, Yang; He, Yan-Hong; Guan, Zhi] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China published Anti-selective direct asymmetric Mannich reaction catalyzed by protease in 2019.0, Cited 69.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
The anti-selective direct asymmetric Mannich reaction of (hetero) aromatic aldehydes, 4-anisidine and O-protected hydroxyacetones for the synthesis of stereodefined anti-beta-amino-alpha-hydroxycarbonyl compounds was developed. Protease type XIV from Streptomyces griseus (SGP) was used as a biocatalyst in 1,4-dioxane/phosphate buffer under mild reaction conditions. The excellent diastereoselectivities of up to >99:1 (anti/syn) and good enantioselectivities of up to 90% ee were achieved. This method provides a more sustainable complement to chemically catalyzed anti-selective direct asymmetric Mannich reactions. (C) 2019 Elsevier Ltd. All rights reserved.
About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Chen, YJ; Xiang, Y; He, YH; Guan, Z or concate me.. Safety of 3-Pyridinecarboxaldehyde
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem