Li, MX; Pu, XJ; Zhang, X; Zheng, X; Gao, H; Xiao, WL; Wan, CP; Mao, ZW in [Li, Min-Xin; Pu, Xiao-Jia; Zhang, Xia; Gao, Hui; Mao, Ze-Wei] Yunnan Univ Chinese Med, Coll Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China; [Zheng, Xi; Wan, Chun-Ping] Yunnan Univ Chinese Med, 1 Affiliated Hosp, Cent Lab, Kunming 650021, Yunnan, Peoples R China; [Xiao, Wei-Lie] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China published Synthesis and Biological Evaluation of Heterocyclic Substituted Bis(indolyl)methanes in 2020.0, Cited 21.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
Background: Bis(indolyl)methane derivatives are widely found in nature with a broad range of biological and pharmacological activities. The development of techniques for the synthesis and functionalization of bis(indolyl)methanes have attracted more and more attention in recent years. Objective: To study the synthesis and biological activity of heterocyclic substituted bis(indolyl)methanes. Materials and Methods: A series of heterocyclic substituted bis(indolyl)methanes (3a-3p) have been prepared by condensation reaction of indole and heterocyclic aldehydes catalyzed by boron trifluoride etherate with high yields. Preliminary in vitro anti-inflammatory in lipopolysaccharide (LIPS)-stimulated RAW-264.7 macrophages and cytotoxic activity against human tumor cell lines (A549, Hela and SGC7901) by MTT assay were tested. Results: The result indicated that heterocyclic substituted bis(indolyl)methanes showed good anti-inflammatory and selective cytotoxic activity. Especially, compounds 3o, 3p and 3q displayed similar inhibitory effect on the generation of NO to positive control dexamethasone, and compound 3q displayed similar selective cytotoxic activity to 5-FU. Conclusion: Heterocyclic substituted bis(indolyl)methanes may be used as potential anti-inflammatory and anticancer leads.
About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, MX; Pu, XJ; Zhang, X; Zheng, X; Gao, H; Xiao, WL; Wan, CP; Mao, ZW or concate me.. Formula: C6H5NO
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem