Authors Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF in SPRINGER published article about NUCLEAR TRANSLOCATION; DIMERS in [Yang, Yang; Zhou, Yuanzheng; Tao, Lei; Yang, Tao; Zhao, Yinglan; Luo, Youfu] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Sichuan, Peoples R China; [Yang, Yang; Zhou, Yuanzheng; Tao, Lei; Yang, Tao; Zhao, Yinglan; Luo, Youfu] Collaborat Innovat Ctr Biotherapy, Chengdu, Sichuan, Peoples R China; [Yang, Tao] Sichuan Univ, West China Hosp, Lab Human Dis & Immunotherapies, Chengdu, Sichuan, Peoples R China in 2021.0, Cited 15.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
Aberrant activation of ERK signaling pathway usually leads to oncogenesis, and small molecular agents targeting this pathway are impeded by the emergence of drug resistance due to reactivation of ERK signaling. Compound DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling. Here, we discussed a structure-activity relationship study of DEL-22379. Forty-seven analogues were designed and synthesized. Each synthesized compound was biologically evaluated for their inhibitory rates on several tumor cell lines and compounds with high inhibitory rates were further evaluated for IC50 values. The structure-activity relationship of idolin-2-one scaffold and the impact of Z/E configuration on potency were discussed. Potential safety of two synthesized analogues was investigated and in silico docking study of five compounds was performed to understand the structural basis of ERK dimerization inhibition. [GRAPHICS] .
About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF or concate me.. SDS of cas: 500-22-1
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem