The important role of 5350-93-6

Statistics shows that 5350-93-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloropyridin-3-amine.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.5350-93-6

A mixture of pyridine 20 (5.37 g, 41.9 mmol) and Boc2O (8.56 g, 46.1 mmol) in DMF (25 mL) and DIEA (5 mL) was stirred at RT for 4 hr, then at 60C for 16 hr. The solution was diluted with AcOEt (300 mL) and was washed with 10% aqueous K2CO3 (2x, each 100 mL). The organic layer was dried [(MGS04)] and evaporated to give compound 21 (8.27 g, [87%, 1H-NMR).]

Statistics shows that 5350-93-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloropyridin-3-amine.

Reference:
Patent; GENESOFT PHARMACEUTICALS, INC.; WO2004/12736; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem