13472-85-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13472-85-0, name is 5-Bromo-2-methoxypyridine. A new synthetic method of this compound is introduced below.
Step j: 2-methoxy-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (Compound R-3-2) A mixture of compound 303 (55 g, 0.29 mol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (90 g, 0.35 mol), potassium acetate (57 g, 0.58 mol) and bis(triphenylphosphine)palladium(II) chloride (2.2 g, 3 mmol) in anhydrous dioxane (500 mL) was heated at 108 C. under N2 atmosphere overnight. The reaction mixture was concentrated and purified by column chromatography eluted with hexanes/ethyl acetate to afford title compound R-3-2 (58 g, 84%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13472-85-0, 5-Bromo-2-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; Curis, Inc.; Cai, Xiong; Zhai, Haixiao; Lai, Chengjung; Qian, Changgeng; Bao, Rudi; (50 pag.)US9249156; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem