Application In Synthesis of Ethyl nicotinate. Recently I am researching about C-H BONDS; CROSS-COUPLING REACTIONS; GRIGNARD-REAGENTS; ENANTIOSELECTIVE FUNCTIONALIZATION; ALKYLIDENE DIHYDROPYRIDINES; REGIOSELECTIVE ADDITION; ARYL HALIDES; ALPHA; PYRIDINES; AZAARENES, Saw an article supported by the Technology Science and Innovation (TIS) Project Grant from F. Hoffmann-La Roche; Natural Sciences and Engineering Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC); York University Graduate Fellowship; NSERCNatural Sciences and Engineering Research Council of Canada (NSERC); Ontario Graduate ScholarshipOntario Graduate Scholarship. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wasfy, N; Rasheed, F; Robidas, R; Hunter, I; Shi, JQ; Doan, B; Legault, CY; Fishlock, D; Orellana, A. The CAS is 614-18-6. Through research, I have a further understanding and discovery of Ethyl nicotinate
We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates readily formed using a ‘soft-enolization’ approach, in a new mechanistic manifold for decarboxylative allylation. Notably, the catalytic generation of pyridylic anions results in a substantially broader functional group tolerance compared to other pyridine allylation methods. Experimental and theoretical mechanistic studies strongly suggest that pyridylic anions are indeed the active nucleophiles in these reactions, and that they participate in an outer-sphere reductive elimination step. This finding establishes a new pK(a) boundary of 35 for soft nucleophiles in transition metal-catalyzed allylations.
Application In Synthesis of Ethyl nicotinate. About Ethyl nicotinate, If you have any questions, you can contact Wasfy, N; Rasheed, F; Robidas, R; Hunter, I; Shi, JQ; Doan, B; Legault, CY; Fishlock, D; Orellana, A or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem