COA of Formula: C6H5NO. In 2020.0 BIOORGAN MED CHEM published article about ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; ORIENTED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; 1-METHYL-3-OXIDOPYRIDINIUM; CHEMISTRY; DISCOVERY; PRODUCTS; KETONES in [Lowe, Robert A.; Nelson, Adam] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England; [Lowe, Robert A.; Nelson, Adam; Marsden, Stephen P.] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England; [Taylor, Dale] Univ Cape Town, H3D Drug Discovery & Dev Ctr, ZA-7700 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, South African Med Res Council, Drug Discovery & Dev Res Unit, ZA-7701 Rondebosch, South Africa in 2020.0, Cited 50.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxy-pyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclisation reactions of, and fusion of additional ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesised and evaluated in order to determine the biological relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries.
Welcome to talk about 500-22-1, If you have any questions, you can contact Lowe, RA; Taylor, D; Chibale, K; Nelson, A; Marsden, SP or send Email.. COA of Formula: C6H5NO
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem