100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
To a round bottom flask connected with condenser, pyridine-2, 5- dicarboxylic acid (20 mmol, 3.34 g), SOCI2 (60 mmol, 7.14 g) and 5 ml_ of DMF were added and the reaction was carried out at 90C under argon for 4 h. The reaction mixture was then cooled down to room temperature, Et3N (6 equiv. , 1 6.8 ml_) and glycerol carbonate (80 mmol, 9.45 g in 1 2 mL of THF) were added slowly and was further heated at 90C overnight. After the reaction, the excess amount of Et3N, SOCI2 and solvent were removed under vacuum. The product bis((2-oxo-1 ,3-dioxolan-4-yl)methyl)pyridine-2,5- dicarboxylate was isolated as a white solid, filtered and washed with water (30 mL, 2 times) and with Et20 (30 mL, 2 times) to give 4.61 g (1 2.6 mmol) of pure product (63%) which was characterized by 1 H, 13C-NMR and HRMS. 1 H- NMR (CDCb, 400 MHz) : 9.1 9 (dd, J = 2.1 , 0.8 Hz, 1 H), 8.49 (dd, J = 8.2, 2.2 Hz, 1 H), 8.21 (dd, J = 8.1 , 0.8 Hz, 1 H), 5.36 – 5.05 (m, 2H), 4.84 – 4.31 (m, 8H). 13C NMR (CDCb, 100 MHz): d= 168.8, 168.6, 159.9, 159.8, 1 55.5, 1 55.4, 143.8, 1 33.2, 1 30.3, 79.4, 79.3, 71 .4, 71 .3, 70.2, 70.1 . HR-MS (ESI) (M+H)+ m/z Calcd. for CisHuNOio: 368.061 2. Found: 368.061 0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.
Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; SEAYAD, Jayasree; JANA, Satyasankar; SEAYAD, Abdul Majeed; (115 pag.)WO2019/190409; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem