624-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 624-28-2, name is 2,5-Dibromopyridine. A new synthetic method of this compound is introduced below.
2,5-Dibromopyridine (10 g, 35.2 mmol) is dissolved in dry toluene (200 mL) under a nitrogen atmosphere and cooled to -78 C. n-Butyllithium (2.5M in hexanes, 2.5 mL, 38.7 mmol) is added at -78 C. over 20 minutes. The reaction mixture is stirred at -78 C. for 20 minutes. Oxetane-3-one (2.79 g, 38.7 mmol) in toluene (100 mL) is added then stirred at -78 C. for 30 minutes. Saturated aqueous ammonium chloride solution (50 mL) is added. The mixture extracted with ethyl acetate (2¡Á200 mL), separated, washed with brine solution (50 mL) and the solvent evaporated under reduced pressure. The crude material is purified using flash chromatography (35% ethyl acetate in hexane) to give the title compound (4.2 g): 1H NMR (400 MHz, DMSO-d6): delta 4.64 (2H, d), 4.87 (2H, d), 6.68 (1H, s), 7.55 (1H, d), 8.06 (1H, dd), 8.76 (1H, d).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ZOETIS LLC; Billen, Denis; Curtis, Michael; Ewin, Richard Andrew; Goodwin, Richard M.; Johnson, Paul D.; Johnson, Timothy Allan; Kyne, Graham M.; Maddux, Todd M.; Sheehan, Susan Mary Kult; Vairagoundar, Rajendran; US2014/88046; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem