Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. 571188-59-5
A mixture of B1 (30.62 g, 110 mmol) and N, N-dimethylformamide (150 mL) was added to the three-necked flask and the mixture was stirred (1.0 M, 120 mL, 120 mmol) was added to a solution of lithium hexamethyldiamine in tetrahydrofuran (20 mL) at 20 to 30 C After the addition of compound 9 (30.58 g, 100 mmol), the reaction was allowed to proceed to room temperature 20 to 25 C for 6 to 8 hours. Reaction end plus (150 mL), extracted with ethyl acetate (150 mL), and the organic phase was washed with saturated brine (150 mL), dried over anhydrous sodium sulfate. After concentration, the compound 12 was separated by a dichloromethane ethyl acetate mixed solvent column chromatography. 46.21 g, 79%)
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Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Wu Yihua; (14 pag.)CN106565707; (2017); A;,
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