98-98-6 , The common heterocyclic compound, 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Methanesulfonic acid, sulfolane and water will be charged into a flask fitted with a magnetic stirrer, reflux condenser, and a temperature probe. To this, o-phenylenediamine (12.96 g, 1 equiv.) and Picolinic acid (15.51, 1.05 equiv.) will be added and the contents of the flask will be refluxed at about 110 C. After 8 h reflux time acetic acid (2 g) will be added and reflux will be maintained for additional about 3 hours to obtain the title compound.
According to the analysis of related databases, 98-98-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ecolab USA Inc.; Cheruku, Pradeep; Sriram, Suresh R.; Michels, James Joseph; US2019/144395; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem