13472-85-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13472-85-0, name is 5-Bromo-2-methoxypyridine. A new synthetic method of this compound is introduced below.
Step A: (5 -bromo-2-methoxyisonicotinaldehyde (39-1)To a solution of diispropylamine (63 g, 642 mmol) in anhydrous THF (500 ml) was added nBuLi (2.5 M, in hexane, 256 mL, 642 mmol) dropwise under a N2 atmosphere at -78 C, and the mixture was stirred for 30 mm. To the reaction mixture was added a solution of 5-bromo-2-methoxypyridine (100 g, 535 mmol) in 100 mL of THF. The reaction mixture was stirred at -78C for lh, and then DMF (50 ml, 642 mmol) was added. After stirring for 30 mm, the reaction mixture was quenched with water and extracted with EtOAc. The organic layer was washed with water and brine, and dried over Na2SO4. After filtration and concentration, the residue was purified by silica gel column chromatography (eluted with petroleum ether: ethyl acetate= 10:1) togive solid 39-1. MS(ESI) mle (M+Hj: 216.0/218.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-85-0, 5-Bromo-2-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William, K.; NARGUND, Ravi, P.; BLIZZARD, Timothy, A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher, W.; DANG, Qun; LI, Bing; LIN, Linus, S.; CUI, Mingxiang; HU, Bin; HAO, Jinglai; CHEN, Zhengxia; WO2014/22528; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem