COA of Formula: C6H5NO. Zhang, W; Mo, JY; He, WY; Kennepohl, P; Sammis, GM in [Zhang, Wei; Mo, Jia Yi; He, Weiying; Kennepohl, Pierre; Sammis, Glenn M.] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada published Regiocontrolled and Stereoselective Syntheses of Tetrahydrophthalazine Derivatives using Radical Cyclizations in 2019.0, Cited 94.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
Tetrahydrophthalazine derivatives have found important applications in pharmaceutical research, but existing synthetic methods are unable to access them regio- and stereoselectively. Here, a new approach is presented that addresses these challenges by utilizing a 6-endo-trig radical cyclization in the key step. The desired tetrahydrophthalazines can be accessed in high yields (55-98 %) and high diastereoselectivities for the trans-product (>95:5) starting either from readily accessible hydrazones, or from the corresponding aldehydes and substituted Boc-hydrazides in a one-pot process. The synthetic versatility of the tetrahydrophthalazine core was demonstrated by its straightforward conversion to dihydro-phthalazines, phthalazines, or pyrazolo dione derivatives. Furthermore, the N-N bond was reduced to afford a new route to 1,4-diamines.
COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Zhang, W; Mo, JY; He, WY; Kennepohl, P; Sammis, GM or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem