In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16063-70-0 as follows., 16063-70-0
767 mg of ethyl 2-cyanopropionate and then 833 mg of potassium carbonate were added to a solution of 500 mg of 2,3,5-trichloropyridine in 5 ml of dimethyl sulfoxide.The reaction was stirred at 100 C. for 5 hours.After completion of the reaction, the reaction solution was cooled to room temperature, 10 ml of water was added, and the mixture was partitioned with 20 ml of ethyl acetate.The obtained organic layer is concentrated under reduced pressure, and the obtained residue is purified by silica gel chromatography (ethyl acetate: hexane = 1: 2)Thus, 270 mg of the desired product was obtained as a colorless oil (yield 49%).
The chemical industry reduces the impact on the environment during synthesis 16063-70-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nissan Chemical Industries, Ltd.; Nakayama, Yosuke; Saito, Fumiyo; Nanju, Yusuke; (53 pag.)JP2019/34892; (2019); A;,
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