Tageldin, GN; Ibrahim, TM; Fahmy, SM; Ashour, HM; Khalil, MA; Nassra, RA; Labouta, IM in [Tageldin, Gina N.; Fahmy, Salwa M.; Ashour, Hayam M.; Khalil, Mounir A.; Labouta, Ibrahim M.] Alexandria Univ, Dept Pharmaceut Chem, Fac Pharm, Alexandria 21521, Egypt; [Ibrahim, Tamer M.] Kafrelsheikh Univ, Pharmaceut Chem Dept, Fac Pharm, Kafr El Shedd 33516, Egypt; [Nassra, Rasha A.] Alexandria Univ, Dept Med Biochem, Fac Med, Alexandria, Egypt published Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d] pyrimidinones and pyrazolo[4,3-e][1,2,4] triazolo[4,3-a] pyrimidinones as anti-inflammatory agents in 2019.0, Cited 53.0. Safety of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
New pyrazolo[3,4-d] pyrimidinone and pyrazolo[4,3-e][1,2,4] triazolo[4,3-a] pyrimidinone derivatives were synthesized. They have been evaluated for their anti-inflammatory activity using in vitro (COX-1/COX-2) inhibitory assay. Moreover, compounds with promising in vitro activity and COX-1/COX-2 selectivity indices were subjected for in vivo anti-inflammatory testing using formalin induced paw edema and cotton-pellet induced granuloma assays for acute and chronic models, respectively. Compounds (2c, 3i, 6a, 8 and 12) showed promising COX-2 inhibitory activity and high selectivity compared to celecoxib. Most of the compounds exhibited potential anti-inflammatory activity for both in vivo acute and chronic models. Almost all compounds displayed safe gastrointestinal profile and low ulcerogenic potential guided by histopathological examination. Furthermore, molecular docking experiments rationalized the observed in vitro anti-inflammatory activity of selected candidates. In silico predictions of the pharmacokinetic and drug-likeness properties recommended accepted profiles of the majority of compounds. In conclusion, this work provides an extension of the chemical space of pyrazolopyrimidinone and pyrazolotriazolopyrimidinone chemotypes for the anti-inflammatory activity.
Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Tageldin, GN; Ibrahim, TM; Fahmy, SM; Ashour, HM; Khalil, MA; Nassra, RA; Labouta, IM or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem