In 2019.0 J ENZYM INHIB MED CH published article about SALMONELLA-TYPHIMURIUM; SERINE ACETYLTRANSFERASE; ANTIBIOTIC-RESISTANCE; SULFUR METABOLISM; DRUG DISCOVERY; CYSTEINE; DESIGN; MECHANISM; PATHOGENS in [Magalhaes, Joana; Annunziato, Giannamaria; Pieroni, Marco; Costantino, Gabriele] Univ Parma, Dept Food & Drug, Grp P4T, Parma, Italy; [Franko, Nina; Benoni, Roberto; Mozzarelli, Andrea; Bettati, Stefano; Campanini, Barbara] Univ Parma, Dept Food & Drug, Lab Biochem & Mol Biol, Parma, Italy; [Nikitjuka, Anna; Jirgensons, Aigars] Latvian Inst Organ Synth, Riga, Latvia; [Mozzarelli, Andrea] Natl Inst Biostruct & Biosyst, Rome, Italy; [Mozzarelli, Andrea] Inst Biophys, Pisa, Italy; [Bettati, Stefano] Univ Parma, Dept Neurosci, Parma, Italy; [Karawajczyk, Anna] Selvita SA, Pk Life Sci, Krakow, Poland; [Costantino, Gabriele] Univ Parma, Ctr Interdipartimentale Misure CIM G Casna, Parma, Italy in 2019.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Safety of 3-Pyridinecarboxaldehyde
The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibitors of enzymes that synthesise cysteine and belong to the reductive sulphur assimilation pathway, absent in mammals. Previous studies have provided a novel series of inhibitors for O-acetylsulfhydrylase – a key enzyme involved in cysteine biosynthesis. Despite displaying nanomolar affinity, the most active representative of the series was not able to interfere with bacterial growth, likely due to poor permeability. Therefore, we rationally modified the structure of the hit compound with the aim of promoting their passage through the outer cell membrane porins. The new series was evaluated on the recombinant enzyme from Salmonella enterica serovar Typhimurium, with several compounds able to keep nanomolar binding affinity despite the extent of chemical manipulation.
Safety of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Magalhaes, J; Franko, N; Annunziato, G; Pieroni, M; Benoni, R; Nikitjuka, A; Mozzarelli, A; Bettati, S; Karawajczyk, A; Jirgensons, A; Campanini, B; Costantino, G or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem