With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52334-81-3, name is 2-Chloro-5-trifluoromethylpyridine, molecular formula is C6H3ClF3N, molecular weight is 181.54, as common compound, the synthetic route is as follows.52334-81-3
2-chloro-5-trifluoromethylpyridine (13.7 g) was dissolved in ethanol (96 ml), thiourea (5.7 g) was added to the mixture, and the mixture was heated to reflux for 3 hours. After allowing the mixture to be cooled to room temperature, an aqueous solution (19.2 ml) of potassium hydroxide (6.4 g) was added to the mixture, and the mixture was heated to reflux for 1 hour. After allowing the mixture to be cooled to room temperature, diluted aqueous solution of potassium hydroxide (20 ml) was added to the mixture, and the mixture was washed with methylene chloride. With acetic acid, pH of the mixture was adjusted to about 6, and the mixture was extracted with methylene chloride. The mixture was washed with water, and dried over magnesium sulfate. The solvent was removed under reduced pressure and the obtained residue was washed with hexane/ethyl acetate, to give 2-mercapto-5-trifluoromethylpyridine (5.1 g). 1H-NMR (200 MHz, CDCl3) delta 4.55 (2H, s), 7.25 to 7.50 (1H, s), 7.59 (2H, d, J = 8.8 Hz), 7.69 (1H, dd, J = 8.4, 2.2 Hz), 8.16 (2H, d, J = 8.8 Hz), 8.69 (1H, s)
Statistics shows that 52334-81-3 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-trifluoromethylpyridine.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem