145100-50-1 ,Some common heterocyclic compound, 145100-50-1, molecular formula is C7H4F6N2O4S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-[iV,lambdar-Bis(trifluoromethansulfonyl)amino]pyridine (13.2 g, 37.0 mmol) was added to a stirred solution ofi-3d-OH (15.6 g, 37.9 mmol), triethylamine (6.50 rnL546.6 mmol) and DMAP (256 mg, 2.10 mmol) in DCM (270 mL) at 0 “C. After approximately 2 h, the reaction mixture was poured into saturated aqueous sodium bicarbonate and extracted three times with EtOAc. The combined organic extracts were washed with saturated aqueous sodium bicarbonate and brine, dried (sodium sulfate) and concentrated in vacuo. The crude residue was purified by flash chromatography on silica gel (gradient elution; 30%-80% EtOAc/hexanes as eluent) to afford i-3d. m/z (ES) 545 (MH)+. 1HNMR (500 MHz, CDCl3): delta 8.97 (s, 2H)5 8.61 (d, IH, J= 3.0 Hz), 7.57 (d, 2H, J= 8.4 Hz), 7.53 (m, IH), 7.53 (d, 2H3 J- 8.0 Hz), 7.37 (d, IH, J= 8.7 Hz)5 5.95 (s, 2H), 3.15 (m, IH), 2.41 (s, 6H)5 1.78 (s, 3H), 0.89 (d, 3H, J= 6.7 Hz), 0.86 (d5 3H, J= 6.9 Hz).
According to the analysis of related databases, 145100-50-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2008/30369; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem