73583-39-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73583-39-8, name is 3-Bromo-5-chloropyridine, molecular formula is C5H3BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To THF (9.0 mL) were successively added dropwise LDA (2.0 mol/L THF solution, 7.2 mL, 14 mmol) andcompound (VII-18) (6.0 mol/L THF solution, 2.0 mL, 12 mmol) at -78¡ãC, and the mixture was stirred for 45 min. Hexachloroethane(6.6 mol/L THF solution, 2.0 mL, 13.2 mmol) was added dropwise at -78¡ãC, and the mixture was stirredfor 30 min, warmed to room temperature and stirred for 1 hr. Saturated aqueous ammonium chloride solution was added,and the mixture was extracted with ethyl acetate. The organic layer was washed successively with saturated aqueousammonium chloride solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporatedunder reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate) togive compound (VII-19) (yield 2.30 g, 85percent) as a yellow solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 73583-39-8, 3-Bromo-5-chloropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
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